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Perfidious Protoplasma is a supplement for the D&D 5th Edition game that expands on oozes and allows them to be used in various environments. It also includes rules for generating ooze, optional class (Itineraant Cytoquixote) with symbiotic relationships as well as mini-dungeons like The Buried Church of the Immortals where an origin theory can pose on Sarkash's ooze population is explored through a minigame. Finally, it includes rules for generating ooze and has various optional classes available to add more depth into your characters' abilities within this world set in medieval Europe with supernatural creatures like oozes roaming around the place that act as enemies or obstacles blocking progress towards certain goals. The supplement also offers additional resources such as maps of different regions, statblocks on specific types of ooze and even a list of common Oozing Monsters (including those found throughout previous D&D supplements). Overall Perfidious Protoplasma is an excellent addition to any group's library that allows for more diverse use cases in the game.